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. 1992 Feb;146(2):182-6.
doi: 10.1001/archpedi.1992.02160140048019.

Vitamin A levels and severity of measles. New York City

T R Frieden  1 , A L Sowell, K J Henning, D L Huff, R A Gunn
Affiliations

Vitamin A levels and severity of measles. New York City

T R Frieden et al. Am J Dis Child. 1992 Feb.

Abstract

Recent studies show that vitamin A levels decrease during measles and that vitamin A therapy can improve measles outcome in children in the developing world. Vitamin A levels of children with measles have not been studied in developed countries. We therefore measured vitamin A levels in 89 children with measles younger than 2 years and in a reference group in New York City, NY. Vitamin A levels in children with measles ranged from 0.42 to 3.0 mumol/L; 20 (22%) were low. Children with low levels were more likely to have fever at a temperature of 40 degrees C or higher (68% vs 44%), to have fever for 7 days or more (54% vs 23%), and to be hospitalized (55% vs 30%). Children with low vitamin A levels had lower measles-specific antibody levels. No child in the reference group had a low vitamin A level. Our data show that many children younger than 2 years in New York City have low vitamin A levels when ill with measles, and that such children seem to have lower measles-specific antibody levels and increased morbidity. Clinicians may wish to consider vitamin A therapy for children younger than 2 years with severe measles. Additional studies of vitamin A in measles and other infectious diseases, and in vaccine efficacy trials, should be done.

Comment in

  • Low vitamin A during measles.
    Rosales FJ, Kjolhede C. Rosales FJ, et al. Am J Dis Child. 1992 Oct;146(10):1133-4. doi: 10.1001/archpedi.1992.02160220019011. Am J Dis Child. 1992. PMID: 1415036 No abstract available.

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